missing translation for 'onlineSavingsMsg'
Learn More
Learn More
MUC-1 Ab-5 Hamster Monoclonal Antibody, Epredia™
Epredia™ MUC-1 Ab-5, Hamster Monoclonal Antibody provides accurate, reproducible results.
£112.00 - £520.00
Specifications
| Antigen | MUC-1 Ab-5 |
|---|---|
| Clone | MH1; same as CT2 |
| Applications | Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot |
| Classification | Monoclonal |
| Conjugate | Unconjugated |
| Product Code | Brand | Quantity | Form | Price | Quantity & Availability | ||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Form | Price | Quantity & Availability | ||||
|
12628606
|
Epredia
HM-1630-P0 |
100 μL | Concentrated | ||||||
|
12638606
|
Epredia
HM-1630-P1 |
500 μL | Concentrated |
 £555.00 £364.89 / 500µL Save £190.11 34% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
|
12618606
|
Epredia
HM-1630-P |
1 mL | Concentrated | ||||||
|
12688606
|
Epredia
HM-1630-R7 |
7 mL | Prediluted | ||||||
Description
Muc1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed in >90% breast carcinomas and metastases. In normal mammary gland it is expressed in apical surface of glandular epithelium. In breast cancer Muc1 is overexpressed; is underglycosylated and the apical localization is lost. Muc1 is transcribed as a larger precursor which is cleaved to form a larger mucin like subunit (265-400kDa) and a smaller subunit (14-28kDa) noncovalently associated with each other. Transgenic Muc1 has been shown to associate with all four erbB receptors and localize with erbB1 (EGFR) in lactating glands1. Muc1 can act as a ligand for ICAM-1 on HUVEC cells; it can bind beta-catenin, GSK3beta and it associates with Grb2-SOS upon phosphorylation.Host Species: Hamster
Clone: MH1 (CT2)
Isotype: IgG
Species Reactivity: Human and Mouse. Others not tested.
Epitope: aa 239-255
Immunogen: A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) from the cytoplasmic tail of MUC-1
Molecular Weight: 14-28kDa
Positive Control: MCF-7 cells; Breast CA
Cellular Localization: Cytoplasmic and membrane
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting
- Immunofluorescence
- Immunoprecipitation
- Flow Cytometry
Note:
USA: RUO; Int'l: RUO
Specifications
| MUC-1 Ab-5 | |
| Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| Unconjugated | |
| RUO | |
| Human, Mouse | |
| IgG |
| MH1; same as CT2 | |
| Monoclonal | |
| Hamster | |
| Cancer and Tumor Biology | |
| A synthetic peptide corresponding to aa 239-255 (SSLSYTNPAVAATSANL) form the cytoplasmic tail of MUC1 | |
| Primary |
Spot an opportunity for improvement?Share a Content Correction
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title