IGF-1R (α-subunit) Ab-4 Mouse Monoclonal Antibody, Epredia™

Epredia™ IGF-1R (α-Subunit) Ab-4, Mouse Monoclonal Antibody provides accurate, reproducible results.

Brand:  Epredia MS-644-P1ABX

Product Code. 12651897

Description

IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of α- and Β-subunits, which are disulfide-linked in a Β-α-α-Β configuration in the mature receptor. The α-subunit is completely extracellular, while the Β-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.

Host Species: Mouse

Clone: 24-60

Isotype: IgG2a/κ

Species Reactivity: Human. Weakly reacts with Rabbit and Pig (Ab-2 is better). Does not react with rat.

Epitope: aa 184-283

Immunogen: IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA

Molecular Weight: 125kDa

Positive Control: Placenta or Breast CA

Cellular Localization: Membrane Ab-4 is excellent for immunoprecipitation of alpha-subunit of IGF-1R.

Recommended for:

• Western Blotting (Not suitable)
• Immunoprecipitation
• Acts as a Weak IGF-like Agonist in Bioassays (Thymidine incorporation into DNA)
• Substantially (>80%) Inhibits IGF-1 Binding

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: IGF-1R (alpha-Subunit) Ab-4
• Classification: Monoclonal
• Concentration: 1mg/mL
• Host Species: Mouse
• Quantity: 100 μL
• Research Discipline: Neuroscience
• Target Species: Human
• Isotype: IgG2a κ

• Applications: Immunoprecipitation
• Clone: 24-60
• Conjugate: Unconjugated
• Immunogen: IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Concentrated