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Epredia™ Lab Vision™ HER-2/c-erbB-2/neu Rabbit Monoclonal Antibody supernatant
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HER2 gene encodes a transmembrane glycoprotein with tyrosine kinase activity. It is closely related in structure to the epidermal growth factor receptor c-erbB-3/HER3/neu oncoprotein. The protein is detectable in a subset of breast and other carcinomas (urinary bladder, stomach, lung, endometrium and ovary). In the case of breast cancer, over expression determined by immunohistochemistry has been shown to be associated with poor prognosis and an indication to initiate trastuzumab/herceptin therapy.
Host Species: Rabbit
Clone: EP1045Y
Isotype: IgG
Species Reactivity: Human. Others not tested.
Epitope: Not determined
Immunogen: A synthetic peptide corresponding to the c-terminus of human Her2
Molecular Weight: 185 kDa
Positive Control: Breast carcinomas
Cellular Localization: Cell membrane
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
Specifications
Specifications
| Antigen | HER-2/c-erbB-2/neu |
| Applications | Immunohistochemistry |
| Clone | EP1045Y |
| Conjugate | Unconjugated |
| Host Species | Rabbit |
| Immunogen | A synthetic peptide corresponding to the c-terminus of human Her2 |
| Quantity | 7 mL |
| Primary or Secondary | Primary |
| Target Species | Human |
| Form | Ready-to-Use |
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