Invitrogen™ L3MBTL2 Monoclonal Antibody (4F4)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA522704

Product Code. 15599152

Beskrivning

Peptide Sequence: RQGSKKPLLE DDPQGARKIS SEPVPGEIIA VRVKEEHLDV ASPDKASSPE LPVSVENIKQ ETDD.

The L3MBTL2 gene encodes a protein that belongs to the MBT (malignant brain tumor) family, which is characterized by the presence of MBT domains. These proteins are known for their role in chromatin organization and transcriptional repression. L3MBTL2 specifically acts as a transcriptional repressor, capable of compacting chromatin independent of histone modifications, thereby facilitating gene silencing. Its repressive activity is associated with the suppression of specific target genes, such as CGA in pancreatic cells, indicating its potential role in regulating cellular differentiation and proliferation. The MBT domains in L3MBTL2 are methyl-lysine readers that further contribute to its role in modulating chromatin state, impacting stem cell maintenance and developmental processes. Understanding L3MBTL2's functions and interactions is crucial due to its involvement in maintaining genomic integrity and its implications in cancer biology, particularly in chromatin-mediated gene regulation mechanisms.

Specifikationer

• Antigen: L3MBTL2
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q969R5
• Gene Symbols: L3MBTL2
• Immunogen: L3MBTL2 (NP_113676, 642 a.a. ~ 705 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: ELISA, Western Blot
• Clone: 4F4
• Conjugate: Unconjugated
• Gene: L3MBTL2
• Gene Alias: 4732493N06Rik; H-l(3)mbt-l; H-l(3)mbt-like protein 2; l(3)mbt-like 2; l(3)mbt-like 2 (Drosophila); l(3)mbt-like 2 protein; L(3)mbt-like protein 2; L3MBT; L3MBTL histone methyl-lysine binding protein 2; L3MBTL2; L3MBTL2 polycomb repressive complex 1 subunit; L3MBTL2, polycomb repressive complex 1 subunit; lethal(3)malignant brain tumor-like 2 protein; lethal(3)malignant brain tumor-like protein 2; lmbt-like 2 (Drosophila) isoform 1; lmbt-like 2 (Drosophila) isoform 2; M4mbt
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 83746
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid