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  6. Invitrogen™ L1RE1 Recombinant Rabbit Monoclonal Antibody (K01_2N10)

Invitrogen™ L1RE1 Recombinant Rabbit Monoclonal Antibody (K01_2N10)

Product Code. 30828825
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30828825 50 μL
30824798 100 μL
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Product Code. 30828825 Supplier Invitrogen™ Supplier No. MA565570

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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: NLRLIGVPES DVENGTKLEN TLQDIIQENF PNLARQANVQ IQEIQRTPQR YSSRRATPRH IIVRFTKVEM KEKMLRAARE KGRVTLKGKP IRLTADLSAE TLQARREWGP IFNILKEKNF QPRISYPAKL SFISEGEIKY FIDKQMLRDF VTTRPALKEL LKEALNMERN NRYQ Highest antigen sequence identity to the following orthologs: Mouse - 45%, Pig - 60%, Cynomolgus monkey - 92%.

L1RE1 encodes a nucleic acid-binding protein, which is essential for retrotransposition of LINE-1 elements in the genome. The proteins act as nucleic acid chaperones binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. Long interspersed element-1/LINE-1/L1 retrotransposons are present in more than 500'000 full (6 kb) or truncated copies in the human genome. Most of them are inactive but one estimate is that 80 to 100 of those elements could be transcribed, translated and active in any individual. An active LINE-1 encodes for 2 proteins translated from a single RNA containing two non-overlapping ORFs, ORF1 and ORF2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen L1RE1
Applications Western Blot
Classification Recombinant Monoclonal
Clone K01_2N10
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 0.05% BSA, 40% glycerol, 150mM NaCl and 0.01% sodium azide; pH 7.4
Gene L1RE1
Gene Accession No. Q9UN81
Gene Symbols L1RE1
Host Species Rabbit
Immunogen Recombinant protein of human LINE-1 ORF1p (aa 157-330).
Purification Method Protein A/G
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4029
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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