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  5. Tocris Bioscience™ L189

Tocris Bioscience™ L189

Product Code. 18014222
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Quantity:
10 mg
Unit Size:
10mg
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Product Code. 18014222

Brand: Tocris Bioscience™ 3561/10

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Description

DNA ligase I, III and IV inhibitor

L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents.
TRUSTED_SUSTAINABILITY

Specifications

Quantity 10 mg
Product Type L189
Molecular Weight (g/mol) 246.29
Inhibitors L189

For Research Use Only

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