L(+)-Amethopterin hydrate, 99%

Artikelnummer.	Quantity	Packaging	unitSize
10491631	100 mg	Glass Bottle	100mg
10002690	25 mg	Glass Bottle	25mg
10066203	500 mg	Glass Bottle	500mg

Artikelnummer. 10491631 Leverandør Thermo Scientific Acros Leverandørnr. 208101000

Beskrivelse

L(+)-Amethopterin hydrate, CAS # 133073-73-1, is an effective inhibitor of dihydrofolate reductase, which may have anti-tumor activity. | CAS: 133073-73-1 | C20H22N8O5 | 454.45 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• L(+)-Amethopterin hydrate, is a potent inhibitor of dihydrofolate reductase
• It has tumoricidal activity

Applications

• L(+)-Amethopterin hydrate is an inhibitor of dihydrofolate reductase
• It can be used in anti-tumor studies
• It is a cell cycle arrest agent, which can inhibit synthesis of DNA, RNA, and proteins
• It can also inhibit production of pro-inflammatory cytokines

Tekniske data

Kemiske identifikatorer

• CAS: 133073-73-1
• Molecular Formula: C20H22N8O5
• Molecular Weight (g/mol): 454.45
• MDL Number: MFCD00150847
• InChI Key: FBOZXECLQNJBKD-UGPWUYPHNA-N
• Synonym: l +-amethopterin dihydrate, methotrexate dihydrate, dihydrate methotrexate, 2s-2-4-2,4-diaminopteridin-6-yl methyl methylamino phenyl carbonylamino pentanedioic acid, hydrate, hydrate
• PubChem CID: 45157423
• IUPAC Name: (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;dihydrate
• SMILES: CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

• Melting Point: 195°C
• Color: Yellow to Orange
• Infrared Spectrum: Authentic
• Assay Percent Range: 98.5% min. (HPLC)
• Packaging: Glass Bottle
• Quantity: 100 mg
• Merck Index: 14, 5985
• Specific Rotation: + 21.5
• Solubility Information: Solubility in water: insoluble in water. Other solubilities: insoluble in alcohol,chloroform,ether,slightly soluble in dilute hydrochloric acid,soluble in dilute solutions of alkali hydroxides a
• Formula Weight: 454.44
• Percent Purity: 99%
• Physical Form: Crystalline Powder
• Chemical Name or Material: L(+)-Amethopterin hydrate

Sikkerhed og håndtering

Produktidentifikator

• L(+)-Amethopterin hydrate

Signalord

• Danger

Farekategori

• Acute toxicity Category 3
• Germ cell mutagenicity Category 1B
• Reproductive toxicity Category 1A

Faresætning

• H360D-May damage the unborn child.
• H340-May cause genetic defects.
• H301-Toxic if swallowed.

Sikkerhedssætning

• P201-Obtain special instructions before use.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
• P308+P313-IF exposed or concerned: Get medical advice/attention.

SDS

RUO – Research Use Only