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L(+)-Amethopterin hydrate, 99%, Thermo Scientific Chemicals

Catalog Number 10066203
284.40 GBP valid until 2024-03-30
Use promo code "21648" to get your promotional price.


210.67 GBP valid until 2024-03-29
Use promo code "21615" to get your promotional price.


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Quantity:
25 mg
100 mg
500 mg
Packaging:
Glass Bottle
This item is not returnable. View return policy
To receive the discount customers must purchase three of the same product at list price in a single order to receive 33.33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”21615” to get your promotional price
133073-73-1
C20H22N8O5
454.45
MFCD00150847
FBOZXECLQNJBKD-UGPWUYPHNA-N
l +-amethopterin dihydrate, methotrexate dihydrate, dihydrate methotrexate, 2s-2-4-2,4-diaminopteridin-6-yl methyl methylamino phenyl carbonylamino pentanedioic acid, hydrate, hydrate
45157423
(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;dihydrate
CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
This item is not returnable. View return policy
To receive the discount customers must purchase three of the same product at list price in a single order to receive 33.33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”21615” to get your promotional price
133073-73-1
C20H22N8O5
454.45
MFCD00150847
FBOZXECLQNJBKD-UGPWUYPHNA-N
l +-amethopterin dihydrate, methotrexate dihydrate, dihydrate methotrexate, 2s-2-4-2,4-diaminopteridin-6-yl methyl methylamino phenyl carbonylamino pentanedioic acid, hydrate, hydrate
45157423
(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid;dihydrate
CN(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

L(+)-Amethopterin hydrate, CAS # 133073-73-1, is an effective inhibitor of dihydrofolate reductase, which may have anti-tumor activity.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description
• L(+)-Amethopterin hydrate, is a potent inhibitor of dihydrofolate reductase
• It has tumoricidal activity
Applications
• L(+)-Amethopterin hydrate is an inhibitor of dihydrofolate reductase
• It can be used in anti-tumor studies
• It is a cell cycle arrest agent, which can inhibit synthesis of DNA, RNA, and proteins
• It can also inhibit production of pro-inflammatory cytokines
TRUSTED_SUSTAINABILITY
Melting Point 195°C
Color Yellow to Orange
Infrared Spectrum Authentic
Assay Percent Range 98.5% min. (HPLC)
Packaging Glass Bottle
Quantity 500 mg
Merck Index 14, 5985
Specific Rotation Condition + 21.50 (20.00°C c=1,14g/l Na2CO3)
Specific Rotation + 21.5
Solubility Information Solubility in water: insoluble in water. Other solubilities: insoluble in alcohol,chloroform,ether,slightly soluble in dilute hydrochloric acid,soluble in dilute solutions of alkali hydroxides a
Formula Weight 454.44
Percent Purity 99%
Physical Form Crystalline Powder
Chemical Name or Material L(+)-Amethopterin hydrate
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Product Identifier
  • L(+)-Amethopterin hydrate
Signal Word
  • Danger
Hazard Category
  • Acute toxicity Category 3
  • Germ cell mutagenicity Category 1B
  • Reproductive toxicity Category 1A
Hazard Statement
  • H360D-May damage the unborn child.
  • H340-May cause genetic defects.
  • H301-Toxic if swallowed.
Precautionary Statement
  • P201-Obtain special instructions before use.
  • P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
  • P308+P313-IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only

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