L-838,417, Tocris Bioscience™

Description

GABAA partial agonist; displays subtype selectivity

Subtype-selective GABAA receptor partial agonist. Selectively binds to α1, α2, α3 and α5 subunits (Ki values are 0.79, 0.67, 0.67 and 2.25 nM respectively) but displays no efficacy at α1 (α1-sparing). Exhibits non-sedative anxiolytic, antinociceptive and anti-inflammatory activity in vivo.

Specifications

• Quantity: 10 mg
• Synonym: unii-8czo0970g3, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy-1,2,4-triazolo 4,3-b pyridazine, 7-tert-butyl-3-2,5-difluorophenyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy-1,2,4 triazolo 4,3-b pyridazine, 5-7-tert-butyl-3-2,5-difluorophenyl-1,2,4 triazolo 4,3-b pyridazin-6-yl oxy methyl-1-methyl-1,2,4-triazole, 1,2,4-triazolo 4,3-b pyridazine, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy, l hplc, 1,2,4-triazolo 4,3-b pyridazine,3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-1-methyl-1h-1,2,4-triazol-5-yl methoxy, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-2-methyl-2h-1,2,4-triazol-3-ylmethoxy-1,2,4-triazolo 4,3-b pyridazine, 3-2,5-difluorophenyl-7-1,1-dimethylethyl-6-1-methyl-1h-1,2,4,-triazol-5-yl methoxy-1,2,4-triazolo 4,3-b pyridazine
• Formula Weight: 399.4
• Percent Purity: >98%
• Chemical Name or Material: L-838, 417