Tocris Bioscience™ KYP 2047

Product Code. 18788006

Brand: Tocris Bioscience™ 6272/25

Description

High affinity prolyl oligopeptidase inhibitor (Ki = 0.023 nM); anti-angiogenic, neuroprotective and brain penetrant

KYP 2047 is a high affinity prolyl oligopeptidase (POP) inhibitor (Ki = 0.023 nM). Clears α-synuclein aggregates induced by oxidative stress in neuronal cells. Inhibits the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Induces angiogenesis via POP inhibition. It reduces tau aggregation in tau-transfected HEK-293 cells and N2A cells as well as in human iPSC-derived neurons from patients with frontotemporal dementia. In vivo, treatment with KYP 2047 of transgenic mice with tauopathy, reduces tau aggregation in the brain and cerebrospinal fluid and slows cognitive decline. Anti-angiogenic and neuroprotective. Brain penetrant.

Specifications

• Chemical Name or Material: (2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
• CAS: 796874-99-2
• Quantity: 25 mg
• Molecular Formula: C₂₀H₂₅N₃O₂
• Formula Weight: 339.44
• Purity: 98%