Invitrogen™ KVbeta2 (KCNAB2) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA568936

Product Code. 15897343

Description

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 83%; Zebrafish: 100%.

Kcnab2 is a voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of potassium channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). Kcnab2 is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. Alternative splicing of the Kcnab2 gene results in multiple transcript variants encoding distinct isoforms. Diseases associated with KCNAB2 include Chromosome 1P36 Deletion Syndrome.

Specifications

• Antigen: KVbeta2 (KCNAB2)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCNAB2
• Gene Alias: AKR6A5; Ckbeta2; F5; HKvbeta2; HKvbeta2.1; HKvbeta2.2; I2rf5; K(+) channel subunit beta-2; KCNA2B; KCNAB2; KCNAB2.1; KCNAB2.2; Kcnb3; KCNK2; KVB2; Kvbeta2; Kv-beta-2; Kvbeta2.1; Kvbeta2.2; neuroimmune protein F5; potassium channel; potassium channel Kv beta 2.1 subunit; potassium channel Kv beta 2.2 subunit; potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2; potassium channel, voltage gated subfamily A regulatory beta subunit 2; potassium channel, voltage-gated shaker-related subfamily A regulatory beta subunit 2; potassium voltage gated channel, shaker related subfamily, beta member 2; potassium voltage-gated channel subfamily A regulatory beta subunit 2; potassium voltage-gated channel, shaker-related subfamily, beta member 2; potassium voltage-gated channel, shaker-related subfamily, beta member 2, transcript variant 1; potassium voltage-gated channel, shaker-related subfamily, beta member 2, transcript variant 2; voltage-gated potassium channel subunit beta-2
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 16498, 8514
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: P62482, Q13303
• Gene Symbols: KCNAB2
• Immunogen: synthetic peptide directed towards the middle region of human KCNAB2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG