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Kv1.2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Product Code. 16812784 Shop All Proteintech Products
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150 μL
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16812784 20 μL 20µL
16802784 150 μL 150µL
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Product Code. 16812784 Supplier Proteintech Supplier No. 142351AP20UL

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Description

Rabbit Polyclonal Antibody

Kcna2 is a voltage-gated potassium channel (KV) that belongs to the 6-TM family of potassium channel and also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of potassium channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). The Kcna2 gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. Kcna2 contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. Further, Kcna2 belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of the Kcna2 gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1. Diseases associated with KCNA2 include Epileptic Encephalopathy (Early Infantile, 32) and Undetermined Early-Onset Epileptic Encephalopathy.

Specifications

Antigen Kv1.2
Applications Western Blot, Immunoprecipitation
Classification Polyclonal
Concentration 0.22 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene KCNA2
Gene Accession No. P16389, P63141, P63142
Gene Alias HBK5, HK4, HUKIV, KCNA2, KV1.2, MK2, NGK1, RBK2
Gene Symbols Kcna2
Host Species Rabbit
Immunogen Kv1.2 Fusion Protein Ag5477
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16490, 25468, 3737
Target Species Rat, Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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