Invitrogen™ KSR1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5110765

Product Code. 17198683

Description

Immunogen sequence: SMIFGVKCKH CRLKCHNKCT KEAPACRISF LPLTRLRRTE SVPSDINNPV DRAAEPHFGT LPKALTKKEH PPAMNHLDSS SNPSSTTSST PSSPAPFPTS SNPSSATTPP NPSPGQRDSR FNFPA Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 96%.

Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown. [UniProt].

Specifications

• Antigen: KSR1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KSR1
• Gene Alias: AW492498; B-KSR1; CAP kinase; D11Bhm183e; D11Bhm184e; hb; HB protein; kinase KSR1; Kinase suppressor of Ras 1; Ksr; KSR1; mKSR1; OTTHUMP00000162931; protein Hb; RSU2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8844
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.10 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IVT5
• Gene Symbols: KSR1
• Immunogen: Recombinant Protein corresonding to Human KSR1. Recombinant protein control fragment (Product #RP-89822).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG