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Invitrogen™ KPNA6 Polyclonal Antibody

Product Code. 12839182
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Quantity:
100 μg
Unit Size:
100µg
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12839182 100 μg 100µg
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Product Code. 12839182 Supplier Invitrogen™ Supplier No. PA521036

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Description

Rabbit Polyclonal Antibody

A suggested positive control is 293 cell lysate. PA5-21036 can be used with blocking peptide PEP-1150.

Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KPNA6
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene KPNA6
Gene Accession No. O35345, O60684
Gene Alias FLJ11249; importin alpha 7 subunit; importin alpha-S2; Importin subunit alpha-7; importin-alpha-S2; IPOA7; karyopherin (importin) alpha 5; karyopherin (importin) alpha 6; karyopherin alpha 6; karyopherin alpha 6 (importin alpha 7); karyopherin subunit alpha 6; karyopherin subunit alpha-6; Kpna5; Kpna6; KPNA7; MGC17918; NPI-2; RP4-622L5.1
Gene Symbols KPNA6
Host Species Rabbit
Immunogen A 13 amino acid peptide near the amino terminus of human KPNA6.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16650, 23633, 362607
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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