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Klotho Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA521078
Code : LD
Additional Details : Weight : 0.01000kg
Description
A suggested positive control is HepG2 cell lysate. PA5-21078 can be used with blocking peptide PEP-1192.
KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.Specifications
Klotho | |
Polyclonal | |
Unconjugated | |
KL | |
alpha-kl; HFTC3; Kl; Klotho; Klotho peptide; secreted form of Klotho protein | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
16591, 83504, 9365 | |
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C | |
Liquid |
Immunohistochemistry, Western Blot | |
1 mg/mL | |
PBS with 0.02% sodium azide | |
O35082, Q9UEF7, Q9Z2Y9 | |
KL | |
A 17 amino acid peptide near the center of human KLOTHO. | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |