Invitrogen™ KLF15 Monoclonal Antibody (2G8)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA515491

Product Code. 11365463

Description

MA5-15491 targets KLF15 in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15491 immunogen is purified recombinant fragment of human KLF15 expressed in E. Coli. MA5-15491 detects KLF15 which has a predicted molecular weight of approximately 44kDa.

KLF15 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. A transcriptional activator, KLF15 binds to the GA element of the CLCNKA promoter and may help to regulate the strict tissue and nephron segment-specific expression of CLCNKA and CLCNKB channel genes. It plays an essential role in adipogenesis in cells through its regulation of PPARG expression. Reports suggest that KLF15 is an inhibitor of cardiac hypertrophy and functions in a pathway, regulating the cardiac response to hemodynamic stress, and regulates mitochondrial acetyl-CoA synthase expression in skeletal muscle. KLF15 may also act as a transcriptional repressor of the rhodopsin and IRBP promoters in the retina, and is a possible participant in repression of photoreceptor-specific gene expression in nonphotoreceptor cells. It is highly expressed in liver, followed by heart, skeletal muscle, and kidney but not expressed in bone marrow or lymphoid tissues.

Specifications

• Antigen: KLF15
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.03% sodium azide
• Gene Accession No.: Q9UIH9
• Gene Symbols: KLF15
• Immunogen: Purified recombinant fragment of human KLF15 expressed in E. Coli.
• Regulatory Status: RUO
• Gene ID (Entrez): 28999
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Western Blot
• Clone: 2G8
• Conjugate: Unconjugated
• Gene: KLF15
• Gene Alias: 1810013I09Rik; AV048136; AW494632; Cardiovascular Krueppel-like factor; CKLF; DKFZp779M1320; Kidney-enriched krueppel-like factor; kidney-enriched Kruppel-like factor; KKLF; KKLF protein; Klf15; KLF15; transcription factor; Krueppel-like factor 15; Kruppel like factor 15; Kruppel-like factor 15
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1