Invitrogen™ KLF10 Monoclonal Antibody (3E11)

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA520125

Product Code. 15558862

Description

Peptide Sequence: LSDTAKPHIA APFKEEEKSP VSAPKLPKAQ ATSVIRHTAD AQLCNHQTCP MKAASILNYQ NNSFRRRTHL NVEAARKNIP CAAVSPNRSK CERNTVADVD.

KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers. KLF10 is a transcriptional repressor involved in the regulation of cell growth and inhibits cell growth. It binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta thus playing a role in linking TGF-beta-mediated signaling cascades to the regulation of pancreatic epithelial cell growth. KLF10 is involved in inducing and promoting apoptosis through the mitochondrial apoptotic pathway and may inhibit Smad7 expression in bronchial epithelial cells. Ubiquitous expression of KLF10 is seen in most of the tissues. Reports suggest that it may mediate up-regulation of TGFBI in VHL-deficient tumors and other cancers. Over expression of KLF10 may be associated with renal clear cell carcinoma and other tumors. KLF11 is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.

Specifications

• Antigen: KLF10
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q13118
• Gene Symbols: KLF10
• Immunogen: KLF10 (AAH11538.1, 111 a.a. ~ 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA, Western Blot, Immunocytochemistry
• Clone: 3E11
• Conjugate: Unconjugated
• Gene: KLF10
• Gene Alias: AI115143; Cpg20; early growth response-alpha; EGR[a]; EGRA; Egral; EGR-alpha; Gdnfif; GDNF-inducible factor; Klf10; Krueppel-like factor 10; Kruppel like factor 10; Kruppel-like factor 10; mGIF; TGFB inducible early growth response; TGFB inducible early growth response 1; TGFB-inducible early growth response protein 1; Tieg; TIEG1; TIEG-1; transcription factor GIF; Transforming growth factor-beta-inducible early growth response protein 1; zinc finger transcription factor homolog CPG20; zinc finger transcription factor TIEG
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 7071
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid