Invitrogen™ KISS1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA557314

Product Code. 15755211

Description

Immunogen sequence: CTERKPAATA RLSRRGTSLS PPPESSGSPQ QPGLSAPHSR QIPAPQGAVL VQREKDLPNY NWNSFGLRFG KREAAPGNHG RS Highest antigen sequence identity to the following orthologs: Mouse - 54%, Rat - 51%.

This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH neurons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.

Specifications

• Antigen: KISS1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KISS1
• Gene Alias: 0610012C01Rik; Eseptin; HH13; KISS1; KiSS-1; KiSS-1 metastasis-suppressor; Kiss1 metastasis-suppressor; Kiss1 variant E1a-E2b-E3; Kiss1 variant E1b-E2a-E3; Kiss1 variant E1b-E2b-E3; kisspeptin; Kisspeptin-1; Kisspeptin-10; Kisspeptin-13; Kisspeptin-14; Kisspeptin-52; Kisspeptin-54; malignant melanoma metastasis-suppressor; metastasis-suppressor KiSS-1; metastatin; metastin; Metastin45-54; MLL septin-like fusion; PP5098; prepro-kisspeptin
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3814
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q15726
• Gene Symbols: KISS1
• Immunogen: Recombinant protein corresponding to Human KISS1. Recombinant protein control fragment (Product #RP-95299).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG