Kir4.1 (KCNJ10) Polyclonal Antibody, Invitrogen™

Guinea Pig Polyclonal Antibody

Brand:  Invitrogen PA5111798

Product Code. 17139713

Description

Reconstitute antibody with 50 μL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Peptide sequence is: (C)KLEESLR EQAEKEGSAL SVR Homology: Human, mouse amino acid residues are identical.

The KIR (for inwardly rectifying potassium channel) family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. KIR4.1, also known as Kir1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. KIR4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human KIR4.1 maps to chromosome 1. KIR4.2, also known as Kir1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human KIR4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and KIR4.2 may play a role in the pathogenesis of Downs syndrome. KIR5.1 forms functional channels only by coexpression with either KIR4.1 or KIR4.2 in the kidney and pancreas.

Specifications

• Antigen: Kir4.1 (KCNJ10)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCNJ10
• Gene Alias: ATP-dependent inwardly rectifying potassium channel Kir4.1; ATP-sensitive inward rectifier potassium channel 10; ATP-sensitive inward rectifier potassium channel KAB-2; BIR10; BIRK1; BIRK-1; BIRK10; BIRK-10; Brain-specific inwardly rectifying K(+) channel 1; Inward rectifier K(+) channel Kir1.2; Inward rectifier K(+) channel Kir4.1; Kab-2; KCNJ10; KCNJ13 PEN; KCNJ13-PEN; Kir1.2; Kir4.1; Potassium channel, inwardly rectifying subfamily J member 10; SESAME
• Host Species: Guinea Pig
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16513, 29718, 3766
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
• Concentration: 0.8 mg/mL
• Formulation: PBS with 1% BSA and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P49655, P78508, Q9JM63
• Gene Symbols: KCNJ10
• Immunogen: Peptide corresponding to amino acid residues 356-375 of rat Kir4.1 (Intracellular, C-terminus)
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG