Invitrogen™ KIR3DL2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA587645

Product Code. 16526091

Description

Positive Samples: HL-60, LO2, MCF7, Mouse spleen, Mouse liver, Rat spleen; Cellular Location: Cell membrane, Single-pass type I membrane protein Immunogen sequence: YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ LDHCVFIQRK ISRPSQRPKT PLTDTSVYTE LPNAEPRSKV VSCPRAPQSG LEGVF.

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals.

Specifications

• Antigen: KIR3DL2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Kir3dl2
• Gene Alias: 3DL2; CD158 antigen-like family member K; CD158K; killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2; killer cell immunoglobulin-like receptor 3DL2; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2; killer Ig receptor; killer immunoglobulin-like receptor-like 2; killer-cell immunoglobulin-like receptor; killer-cell immunoglobulin-like receptor 3DL2; KIR antigen 3DL2; KIR3DL2; KIR-3DL2; Kirl2; KIR-like receptor 2; LOC727787; MHC class I NK cell receptor; natural killer cell receptor; natural killer-associated transcript 4; NKAT4; NKAT-4; NKAT4B; p140; p70 killer cell inhibitory receptor; p70 natural killer cell receptor clone CL-5; p70 NK receptor CL-5
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 245615, 3812
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.65 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P43630
• Gene Symbols: Kir3dl2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 361-455 of human KIR3DL2 (NP_0067282).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG