KIR3DL1 Mouse anti-Human, Monkey, Rat, Clone:6D9F6, Abnova™

Mouse monoclonal antibody raised against recombinant human KIR3DL1.

Brand:  Abnova MAB17616.100ug

Product Code. 16074896

Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq]

Specifications

• Antigen: KIR3DL1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:10000)
  Western Blot (1:500-1:2000)
  Immunocytochemistry
  Flow Cytometry
  Immunohistochemistry (1:200-1:1000)
  The optimal working dilution should be determined by the end user.
• Gene: KIR3DL1
• Host Species: Mouse
• Quantity: 100 μg
• Target Species: Human, Monkey, Rat
• Product Type: Antibody
• Isotype: IgG2b

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 6D9F6
• Description: killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
• Formulation: In PBS (0.05% sodium azide)
• Gene Alias: CD158E1, KIR, MGC119726, MGC119728, MGC126589, MGC126591, NKAT3, NKB1, NKB1B
• Immunogen: Recombinant protein corresponding to amino acid 22-340 of human KIR3DL1 from E. coli.
• Gene ID (Entrez): 3811
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid