Invitrogen™ Kir2.2 (KCNJ12) Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA555485

Product Code. 15793401

Description

Immunogen sequence: RCSAKDLVEN KFLLPSANSF CYENELAFLS RDEEDEADGD QDGRSRDGLS PQARHDFDRL QAGGGVLEQR PYRRESEI Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 81%.

Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Specifications

• Antigen: Kir2.2 (KCNJ12)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Kcnj12
• Gene Alias: ATP-sensitive inward rectifier potassium channel 12; atrium potassium channel IRK; DirK; hIRK; hIRK1; hkir2.2x; Inward rectifier K(+) channel Kir2.2; inward rectifier K(+) channel Kir2.2v; inward rectifier K(+) channel Kir2.6; inward rectifier potassium channel Kir2.2; inwardly-rectifying potassium channel KCNJ12; inwardly-rectifying potassium channel Kir2.2; IRK; Irk2; IRK-2; KCNJ12; kcnj12x; KCNJN1; Kir2.1; Kir2.2; Kir2.2v; MB-IRK2; potassium channel, inwardly rectifying subfamily J member 12; potassium channel, inwardly rectifying subfamily J, member 12; potassium inwardly rectifying channel subfamily J member 12; potassium inwardly-rectifying channel J12; potassium inwardly-rectifying channel, subfamily J, inhibitor 1; potassium inwardly-rectifying channel, subfamily J, member 12; potassium voltage-gated channel subfamily J member 12; subfamily J, member 12
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3768
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.5 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q14500
• Gene Symbols: Kcnj12
• Immunogen: Recombinant protein corresponding to Human KCNJ12. Recombinant protein control fragment (Product #RP-91128).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG