Invitrogen™ Kininogen 1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA581961

Product Code. 16398924

Description

Immunogen sequence: LFLTPDCKSL WNGDTGECTD NAYIDIQLRI ASFSQNCDIY PGKDFVQPPT KICVGCPRDI PTNSPELEET LTHTITKLNA ENNATFYFKI DNVKKARVQV VAGKKYFIDF VARETTCSKE SNEELTESCE TK Highest antigen sequence indentity to the following orthologs: Mouse - 59%, Rat - 58%.

This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: Kininogen 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KNG1
• Gene Alias: alpha-1-MAP; Alpha-2-thiol proteinase inhibitor; BDK; BK; Bradykinin; fitzgerald factor; high molecular weight kininogen; H-kininigen; HMWK; Ile-Ser-Bradykinin; Kallidin I; Kallidin II; kininogen; kininogen 1; kininogen 1-like 1; kininogen-1; Kininogen-1 heavy chain; Kininogen-1 light chain; Kng; Kng1; Kng1l1; L-kininogen; low molecular weight (LMW) T-kininogen II; Low molecular weight growth-promoting factor; Lysyl-bradykinin; Major acute phase protein; major acute phase protein (alpha-1-MAP); Thiostatin; T-kinin; T-kininogen 2; T-kininogen 2 heavy chain; T-kininogen 2 light chain; T-kininogen II; T-kininogen II heavy chain; T-kininogen II light chain; williams-Fitzgerald-Flaujeac factor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3827
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P01042
• Gene Symbols: KNG1
• Immunogen: Recombinant protein corresponding to Human KNG1. Recombinant protein control fragment (Product #RP-100524).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG