Invitrogen™ Kindlin 3 Polyclonal Antibody

Goat Polyclonal Antibody

Brand:  Invitrogen™ PA519174

Product Code. 11337153

Description

This antibody is predicted to react with canine, mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 2,000.

The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.

Specifications

• Antigen: Kindlin 3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Fermt3
• Gene Alias: C79673; fermitin family homolog 3; fermitin family homolog 3 (Drosophila); fermitin family member 3; Fermt3; Kind3; kindlin 3; Kindlin3; Kindlin-3; MGC10966; MIG-2; MIG2B; MIG2-like protein; RGD1310168; UNC-112 related protein 2; UNC112C; unc-112-related protein 2; URP2; URP2SF
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 83706
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q86UX7
• Gene Symbols: Fermt3
• Immunogen: Synthetic peptide sequence (ERARGEELDED) corresponding to the C-terminus amino acids of FERMT3 (aa 645-656).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG