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Invitrogen™ Kindlin 3 Polyclonal Antibody

Product Code. 12848772
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Quantity:
100 μg
Unit Size:
100µg
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12848772 100 μg 100µg
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Product Code. 12848772 Supplier Invitrogen™ Supplier No. PA520598

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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat spleen tissue lysate. PA5-20598 can be used with blocking peptide PEP-0718.

The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Kindlin 3
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Fermt3
Gene Accession No. Q86UX7, Q8K1B8
Gene Alias C79673; fermitin family homolog 3; fermitin family homolog 3 (Drosophila); fermitin family member 3; Fermt3; Kind3; kindlin 3; Kindlin3; Kindlin-3; MGC10966; MIG-2; MIG2B; MIG2-like protein; RGD1310168; UNC-112 related protein 2; UNC112C; unc-112-related protein 2; URP2; URP2SF
Gene Symbols Fermt3
Host Species Rabbit
Immunogen A 19 amino acid peptide near the carboxy terminus of the human KINDLIN3.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 108101, 309186, 83706
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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