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KIF3A Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Product Code. 16852364 Shop All Proteintech Products
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Quantity:
150 μL
20 μL
Unit Size:
150µL
20µL
Product Code. Quantity unitSize
16852364 20 μL 20µL
16842364 150 μL 150µL
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Product Code. 16852364

Brand: Proteintech 139301AP20UL

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This item is not returnable. View return policy

Description

Rabbit Polyclonal Antibody

This antibody specifically recognizes the endogenous KIF3A protein in mouse embryonic fibroblasts (MEFs) but not in KIF3A-/- lysate.

The kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. Members of the heterotrimeric kinesin II family of microtubule associated motors generally contain two different motor subunits from the KIF3 family, which includes KIF3A, B and C. KIF3 isoforms mediate anterograde transport of membrane bound organelles in neurons and melanosomes, transport between the endoplasmic reticulum and the Golgi, and transport of protein complexes within cilia and flagella required for their morphogenesis. KIF3A may influence neurogenesis at the level of embryonic cellular events, where the asymmetry of the genetic control circuit controlling left-right (L-R) axis determination is defined. Loss of KIF3A function in mice photoreceptors causes apoptotic cell death, suggesting that kinesin II mediated transport is required for proper cell fate.

Specifications

Antigen KIF3A
Applications Western Blot, Immunohistochemistry (Paraffin), Immunoprecipitation
Classification Polyclonal
Concentration 0.19 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene KIF3A
Gene Accession No. P28741, Q9Y496
Gene Alias KIF3, KIF3A, kinesin family member 3A, Kinesin like protein KIF3A
Gene Symbols Kif3a
Host Species Rabbit
Immunogen KIF3A Fusion Protein Ag4954
Purification Method Antigen Affinity Chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11127, 16568
Target Species Mouse, Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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