KI67 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16885555	Proteintech 27309-1-AP-20UL	20 μL
16875555	Proteintech 27309-1-AP-150UL	150 μL

Description

Ki-67 is a nuclear protein that is expressed during various stages in the cell cycle, particularly during late G1, S, G2, and M phases. The protein has a forkhead associated domain (FHA) through which it associates with euchromatin at the perichromosomal layer, the centromeric heterochromatin, and the nucleolus. Ki-67 is shown to have a cell cycle dependent topographical distribution with perinucleolar expression at G1, expression in the nuclear matrix at G2, and expression on the chromosomes during M phase. Ki-67 is commonly used as a proliferation marker because it is not detected in G0 cells, but increases steadily from G1 through mitosis. Ki-67 antibodies are useful in establishing the cell growing fraction in neoplasms. In neoplastic tissues, the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki-67 index and histologically low-grade tumors is strong. Ki-67 is routinely used as a neuronal marker of cell cycling and proliferation.

Specifications

• Antigen: KI67
• Applications: Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: P46013
• Gene ID (Entrez): 4288
• Immunogen: KI67 Fusion Protein Ag26266
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: MKI67

• Concentration: 0.6 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: Antigen KI 67, Ki 67, KI67, KIA, MKI67
• Gene Symbols: MKI67
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody