Invitrogen™ KCNN3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA596511

Product Code. 16529351

Description

Immunogen sequence: VARKLELTKA EKHVHNFMMD TQLTKRIKNA AANVLRETWL IYKHTKLLKK IDHAKVRKHQ RKFLQAIHQL RSVKMEQRKL SDQANTLVDL SKMQNVMYDL ITELNDRSED LEKQIGSLES KLEHLTASFN SLPLLIADTL RQQQQQLLSA IIEARGVSVA VGTTHTPISD SPIGVSSTSF PTPYTSSSSC; Positive Samples: NCI-H460; Cellular Location: Membrane, Multi-pass membrane protein.

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. KCNN3, a member of the KCNN family of potassium channel genes, encodes a protein that is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits.

Specifications

• Antigen: KCNN3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCNN3
• Gene Alias: hSK3; K3; KCa2.3; Kcnn3; potassium calcium-activated channel subfamily N member 3; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; SK3; SKCa 3; SKCa3; small conductance calcium-activated potassium channel 3; small conductance calcium-activated potassium channel protein 3; small-conductance Ca2+-activated K+ channel 3
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3782
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.16 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9UGI6
• Gene Symbols: KCNN3
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 237-426 of human KCNN3 (NP_7407521).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG