KCNMA1 Polyclonal Antibody, Invitrogen™

Guinea Pig Polyclonal Antibody

Brand:  Invitrogen PA5111800

Product Code. 17159713

Description

Reconstitute antibody with 50 μL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). GST fusion protein sequence is: SHSSHSSQS SSKKSSSVHS IPSTANRPNR PKSRESRDKQ NATRMTRMGQ AEKKWFTDEP DNAYPRNIQI KPMSTHMANQ INQYKSTSSL IPPIREVEDE C Homology: Mouse - 21/21 amino acid residues identical to the canonical sequence (AccessionQ08460); rat - 20/21 amino acid residues identical to the canonical sequence (AccessionQ62976); human - 19/21 amino acid residues identical to the canonical sequence (AccessionQ12791).

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.

Specifications

• Antigen: KCNMA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Kcnma1
• Gene Alias: 5730414M22Rik; bA205K10.1; BK channel; BKCa; BKCA alpha; BKTM; Calcium-activated potassium channel subunit alpha-1; Calcium-activated potassium channel, subfamily M subunit alpha-1; hSlo; K(VCA)alpha; KCa1.1; Kcnma; KCNMA1; KCNMA1b; KCNMA1c; Maxi K channel; MaxiK; Maxi-K channel HSLO; mSlo; mSlo1; SAKCA; SLO; Slo homolog; Slo1; Slo-alpha; Slowpoke homolog
• Host Species: Guinea Pig
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16531, 3778, 83731
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Western Blot
• Concentration: 0.8 mg/mL
• Formulation: PBS with 1% BSA and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q08460, Q12791, Q62976
• Gene Symbols: Kcnma1
• Immunogen: GST fusion protein corresponding to residues 1097-1196 of mouse KCNMA1variant 2 (Intracellular, C-terminus)
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG