Invitrogen™ KCNK3 Monoclonal Antibody (N374/48), PerCP

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA545703

Product Code. 17825702

Description

Mouse: 96% identity (156/161 amino acids identical). Human: 76% identity (163/161 amino acids identical). <30% identity with TASK3. 1 μg/mL of MA5-45703 was sufficient for detection of TASK1 Potassium Channel in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 50kDa. Does not cross-react with TASK3. This antibody was formerly sold as clone S374-48.

KCNK3 encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The gene product is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.

Specifications

• Antigen: KCNK3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
• Gene Accession No.: O14649, O35111, O54912
• Gene Symbols: KCNK3
• Immunogen: Fusion protein amino acids 251-411 (cytoplasmic C-terminus) of rat Acid-sensitive potassium channel protein TASK or TASK1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Clone: N374/48
• Conjugate: PerCP
• Gene: KCNK3
• Gene Alias: acid-sensitive potassium channel protein TASK; acid-sensitive potassium channel protein TASK-1; cardiac potassium channel; cardiac two pore background K(+) channel; Ctbak; cTBAK 1; cTBAK-1; K2p3.1; KCNK3; KCNK9; LOW QUALITY PROTEIN: potassium channel subfamily K member 3; OAT1; Potassium channel subfamily K member 3; potassium channel subfamily K member 3; LOW QUALITY PROTEIN: potassium channel subfamily K member 3; potassium channel, subfamily K, member 3; potassium channel, two pore domain subfamily K, member 3; potassium inwardly-rectifying channel, subfamily K, member 3; potassium two pore domain channel subfamily K member 3; PPH4; rTASK; TASK; TASK 1; TASK1; TASK-1; TASK-1 ion channel receptor; TASK-related potassium channel; TBAK1; TWIK-related acid-sensitive K(+) channel 1; TWIK-related acid-sensitive K+ channel; two P domain potassium channel; two pore K(+) channel KT3.1; Two pore potassium channel KT3.1
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 16527, 29553, 3777
• Content And Storage: 4°C
• Form: Liquid