KCNK18 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 23712-1-AP-20UL

Product Code. 16882415

Description

This antibody can be used to detect endogenous KCNK18, however, the reason for the additional band of 130-140 kDa is still unknown.

TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.

Specifications

• Antigen: KCNK18
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCNK18
• Gene Alias: K2p18.1, KCNK18, TRESK, TRESK 2, TRESK2, TRIK
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 338567
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunofluorescence, Immunocytochemistry
• Concentration: 0.45 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q7Z418
• Gene Symbols: KCNK18
• Immunogen: KCNK18 Fusion Protein Ag20514
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG