Kanamycin sulfate from Streptomyces kanamycetikus, MP Biomedicals™

Product Code. 11400056

Brand: MP Biomedicals 0219985301

Description

Kanamycin sulfate from Streptomyces kanamycetikus USP Grade, White Powder

• It is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus.
• It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium.
• Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene.
• Kanamycin sulfate is an antimicrobial agent effective against Gram-negative and Gram-positive bacteria and mycoplasma.
• It binds to the 70S ribosomal subunit, inhibits translocation, and elicits miscoding.
• Cross-resistance occurs between kanamycin and neomycin, framycetin, and paromomycin, and partial cross-resistance has been reported between kanamycin and streptomycin. Aminoglycosidemodifying enzymes (acetyltransferase, phosphotransferase, nucleotidyltransferase) alter the antibiotic, preventing its interaction with ribosomes.

Specifications

Chemical Identifiers

• CAS: 25389-94-0
• Molecular Formula: C18H38N4O15S
• Molecular Weight (g/mol): 582.58
• MDL Number: MFCD00070253
• InChI Key: OOYGSFOGFJDDHP-KMCOLRRFSA-N
• Synonym: Kanamycin A, Kanamycin sulfate salt
• PubChem CID: 134129479

• Physical Form: Powder
• pH: 6.5 to 8.5 (1% solution)
• Melting Point: >250°C
• Loss on Drying: <4%
• Potency: >750 µg/mg
• Color: White
• Quantity: 1 g
• Solubility Information: Soluble in 10-50mg/mL of Water
• Grade: USP

Safety and Handling

Signal Word

• Danger

Hazard Category

• Reproductive toxicity Category 1A

Hazard Statement

• H360-May damage fertility or the unborn child.

Precautionary Statement

• P201-Obtain special instructions before use.
• P202-Do not handle until all safety precautions have been read and understood.
• P281-Use personal protective equipment as required.
• P308+P313-IF exposed or concerned: Get medical advice/attention.
• P405-Store locked up.
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.