Kanamycin monosulfate, Thermo Scientific™

Kanamycin monosulfate, CAS # 25389-94-0, is an aminoglycoside sulfate salt with antibacterial activity.

Brand:  Thermo Scientific Alfa Aesar J61272.09

Product Code. 15473879

Description

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

General Description

• Kanamycin monosulfate is the sulfate salt form of kanamycin A
• It was isolated from Streptomyces kanamyceticus
• This compound inhibits translocation during protein biosynthesis. It binds to the 30S ribosomal subunit, causing misreading of the mRNA sequence

Application

• Kanamycin monosulfate shows antibacterial activity. It is effective against gram-positive and gram-negative bacteria, as well as Mycoplasma species
• This compound is also involved in translating prokaryotic ribosomes
• In molecular biology experiments, it is commonly used to select and isolate transformants expressing the kanamycin resistance gene, and plants that have the NPT II (APH3) gene incorporated

Chemical Identifiers

• CAS: 25389-94-0
• Molecular Weight (g/mol): 582.575
• InChI Key: OOYGSFOGFJDDHP-IZQIRFRQSA-N
• PubChem CID: 134129479
• SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)O)O)OC3C(C(C(C(O3)CO)O)N)O)N.OS(=O)(=O)O

• Molecular Formula: C18H38N4O15S
• MDL Number: MFCD00070253
• Synonym: Kanamycin A
• IUPAC Name: (2R,3S,4S,5S,6R)-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5R,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid

Specifications

• CAS: 25389-94-0
• Quantity: 10g
• MDL Number: MFCD00070253
• Synonym: Kanamycin A
• InChI Key: OOYGSFOGFJDDHP-IZQIRFRQSA-N
• IUPAC Name: (2R,3S,4S,5S,6R)-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5R,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid
• PubChem CID: 134129479
• Chemical Name or Material: Kanamycin monosulfate

• Color: White
• Molecular Formula: C18H38N4O15S
• Merck Index: 14,5281
• Solubility Information: Dissolve in water at 10mg/ml.Soluble in water.
• SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)O)O)OC3C(C(C(C(O3)CO)O)N)O)N.OS(=O)(=O)O
• Molecular Weight (g/mol): 582.575
• Formula Weight: 582.58

Safety and Handling

Product Identifier

• Kanamycin monosulphate

Signal Word

• Danger

Hazard Category

• Reproductive toxicity Category 1B
• Respiratory sensitiser Category 1
• Skin sensitiser Category 1

Hazard Statement

• H317-May cause an allergic skin reaction.
• H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
• H360FD-May damage fertility. May damage the unborn child.

Precautionary Statement

• P201-Obtain special instructions before use.
• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P308+P313-IF exposed or concerned: Get medical advice/attention.
• P342+P311-If experiencing respiratory symptoms: Call a POISON CENTER/doctor/ .

Supplemental information

• MIXTURE LIST-Contains : Kanamycin sulphate