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Tocris Bioscience™ JZL 184
Description
Potent and selective MAGL inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM). Potentiates depolarization-induced suppression of excitability in cerebellar Purkinje neurons. Exhibits >300-fold selectivity for MAGL over FAAH in vitro. Attenuates nociception in neuropathic and inflammatory pain models. Also reduces free fatty acid levels in primary tumors.
Specifications
Specifications
| Quantity | 50 mg |
| Formula Weight | 520.49 |
| Purity | >98% |
| Molecular Weight (g/mol) | 520.494 |
| Chemical Name or Material | JZL 184 |
Product Title
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