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  5. Tocris Bioscience™ JW 74

Tocris Bioscience™ JW 74
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Product Code. 18727668
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18727668 50 mg 50mg
18717189 10 mg 10mg
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Product Code. 18727668 Supplier Tocris Bioscience™ Supplier No. 5653/50

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Description

Wnt pathway inhibitor

JW 74 is an inhibitor of canonical Wnt signaling (IC50 = 790 nM). Targets the β-catenin destruction complex (GSK-3?/AXIN/APC). Increases AXIN2 and decreases active β-catenin levels in colorectal cancer (CRC) cells. Also arrests cell cycle in G1 and inhibits proliferation of CRC cells in vitro. Inhibits tumor growth and formation in mouse models.
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Specifications

Chemical Name or Material 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine
CAS 863405-60-1
Quantity 50 mg
Solubility Soluble to 100mM in DMSO
Molecular Formula C24H20N6O2S
Formula Weight Observed MW: 456.52
Purity >99%

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