JTB Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Thermo Scientific PA552307

Product Code. 15720261

Description

Immunogen sequence: EEKLSASTSN LPCWLVEEFV VAEECSPCSN FRAKTTPECG PTGYVEKITC SSSKRNEFKS CRSALMEQRL Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 86%.

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.

Specifications

• Antigen: JTB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: JTB
• Gene Alias: hJT; HJTB; HSPC222; Jtb; jumping translocation breakpoint; jumping translocation breakpoint protein; PAR; PAR protein; Prostate androgen-regulated protein; protein JTB
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10899
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O76095
• Gene Symbols: JTB
• Immunogen: Recombinant protein corresponding to Human JTB
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Research Use Only