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Invitrogen™ JPH3 Polyclonal Antibody

Product Code. 12828792
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Quantity:
100 μg
Unit Size:
100µg
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12828792 100 μg 100µg
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Product Code. 12828792 Supplier Invitrogen™ Supplier No. PA520643

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Description

Rabbit Polyclonal Antibody

A suggested positive control is Daudi cell lysate. PA5-20643 can be used with blocking peptide PEP-0763.

Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain. In the CNS, both JPH3 and JPH4 are expressed throughout neural sites and contribute to the subsurface cistern formation in neurons. Mice lacking both JPH3 and JPH4 subtypes exhibit serious symptoms such as impaired learning and memory and are accompanied by abnormal nervous functions. A repeat expansion in JPH3 is associated with Huntington disease-like 2. At least two isoforms of JPH3 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen JPH3
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene JPH3
Gene Accession No. Q8WXH2, Q9ET77
Gene Alias CAGL237; HDL2; JP3; JP-3; JPH3; junctophilin 3; junctophilin type 3; Junctophilin-3; TNRC22; trinucleotide repeat containing 22; Trinucleotide repeat-containing gene 22 protein
Gene Symbols JPH3
Host Species Rabbit
Immunogen An 18 amino acid peptide near the carboxy terminus of human JPH3.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 307916, 57338, 57340
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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