ACROBiosystems Biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His, Avitag™&Tag Free

Product Code. 16467809

Brand: ACROBiosystems IT7H82W9200ug

Description

Biotinylated Protein

Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer’s patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).

Biotinylated Human ITGA4&ITGB7 Heterodimer Protein, His,Avitag&Tag Free, produced by co-expression of ITGA4 and ITGB7, has a calculated MW of 113.2 kDa (ITGA4) and 81.8 kDa (ITGB7). Subunit ITGA4 is fused with an acidic tail at the C-terminus and followed

Specifications

• Accession Number: NP 000876.3 (ITGA4) and NP_000880.1 (ITGB7)
• Molecular Weight (g/mol): 113.2 kDa (ITGA4) and 81.8 kDa (ITGB7)
• Quantity: 200 μg
• Source: Biotinylated Human ITGA4&ITGB7; Heterodimer Protein, His,Avitag&Tag; Free (IT7-H82W9) is expressed from human 293 cells (HEK293). It contains AA Tyr 34 - Thr 977 (ITGA4) and Glu 20 - His 723 (ITGB7) (Accession # P13612-1 (ITGA4) and P26010-1 (ITGB7)).
• Immunogen: Tyr 34 - Thr 977 (ITGA4) and Glu 20 - His 723 (ITGB7)
• Storage Requirements: -20°C
• Gene Alias: Integrin alpha 4 beta 7,ITGA4andITGB7
• Common Name: Integrin alpha 4 beta 7
• Conjugate: Precision Avi
• Species: Human
• Protein Tag: His Tag and Avi Tag
• Expression System: HEK293
• Form: Powder
• Protein Subtype: MABSol™ Biotin Labeled Proteins