missing translation for 'onlineSavingsMsg'
Learn More
Learn More
JMY Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA560317
This item is not returnable.
View return policy
Description
Immunogen sequence: VSSVRIVSAS GTVSEEIEVL EMVKEDEAPL ALSDAEQPPP ATELESPAEE CSWAGLFSFQ DLRAVHQQLC SVNSQLEPCL PVFPEEPSGM WTVLF Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 87%.
JMY acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.Specifications
JMY | |
Polyclonal | |
Unconjugated | |
JMY | |
FLJ37870; JMY; junction mediating and regulatory protein, p53 cofactor; junction-mediating and regulatory protein; junction-mediating and -regulatory protein; LOC683593; p300 transcriptional cofactor JMY; similar to junction-mediating and regulatory protein; WAS protein homology region 2 domain containing 1-like 3; WHAMM2; WHDC1L3 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
133746 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry, Western Blot | |
0.3 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q8N9B5 | |
JMY | |
Recombinant protein corresponding to Human JMY | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Research Use Only