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Invitrogen™ JMJD4 Polyclonal Antibody

Product Code. 12848982
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Quantity:
100 μg
Unit Size:
100µg
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12848982 100 μg 100µg
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Product Code. 12848982 Supplier Invitrogen™ Supplier No. PA520805

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Description

Rabbit Polyclonal Antibody

A suggested positive control is human spleen tissue lysate. PA5-20805 can be used with blocking peptide PEP-0919.

Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
TRUSTED_SUSTAINABILITY

Specifications

Antigen JMJD4
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Jmjd4
Gene Accession No. Q9H9V9
Gene Alias 2-oxoglutarate- and Fe(II)-dependent oxygenase; 2-oxoglutarate and iron-dependent oxygenase JMJD4; 6430559I23; C4 lysyl hydroxylase; jmjC domain-containing protein 4; JMJD4; jumonji domain containing 4; jumonji domain-containing protein 4; Lysyl-hydroxylase JMJD4; RGD1307186
Gene Symbols Jmjd4
Host Species Rabbit
Immunogen A 17 amino acid peptide from near the amino terminus of human JMJD4.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 287359, 65094
Target Species Human, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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