JMJD3 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA535012

Product Code. 15337444

Description

This antibody is predicted to react with mouse based on sequence homology.

Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

Specifications

• Antigen: JMJD3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KDM6B
• Gene Alias: 1700064E03Rik; BC038313; jmjC domain-containing protein 3; JMJD3; jumonji domain containing 3; jumonji domain containing 3, histone lysine demethylase; jumonji domain-containing 3; jumonji domain-containing protein 3; KDM1 lysine (K)-specific demethylase 6B; Kdm6b; KIAA0346; lysine (K)-specific demethylase 6B; lysine demethylase 6B; Lysine-specific demethylase 6B; mKIAA0346
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 23135
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: O15054
• Gene Symbols: KDM6B
• Immunogen: KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human JMJD3
• Quantity: 200 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG