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Invitrogen™ JMJD1C Polyclonal Antibody

Product Code. 12828982
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Quantity:
100 μg
Unit Size:
100µg
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12828982 100 μg 100µg
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Product Code. 12828982 Supplier Invitrogen™ Supplier No. PA520804

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Description

Rabbit Polyclonal Antibody

A suggested positive control is human liver tissue lysate. PA5-20804 can be used with blocking peptide PEP-0918.

The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the nuclear hormone receptor-based transcriptional regulation. JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells as well as pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. The JMJD1C gene promoter contain bHLH-, AP-1-, and POU5F1-binding sites, and as preferential expression of POU5F1 has been reported in ES cells, pancreatic islet, and diffuse-type gastric cancer, it has been suggested that POU5F1-mediated expression of JMJD1C reactivates previously silenced genes in ES cells and diffuse-type gastric cancer. At least three isoforms of JMJD1C are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen JMJD1C
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene JMJD1C
Gene Accession No. Q15652, Q69ZK6
Gene Alias 5430433L24Rik; D630035I23Rik; DKFZp761F0118; FLJ14374; Jhdm2c; JMJD1C; Jmjdic; jumonji domain containing 1C; jumonji domain-containing protein 1C; Kiaa1380; Pr2; Probable JmjC domain-containing histone demethylation protein 2C; RP11-10C13.2; thyroid hormone receptor interactor 8; thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP8; TRIP-8
Gene Symbols JMJD1C
Host Species Rabbit
Immunogen A 20 amino acid peptide from near the amino terminus of human JMJD1C.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 108829, 171120, 221037
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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