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  5. Tocris Bioscience™ JHU 37152

Tocris Bioscience™ JHU 37152
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Product Code. 18749286
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18749286 10 mg 10mg
18708886 50 mg 50mg
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Product Code. 18749286 Supplier Tocris Bioscience™ Supplier No. 7197/10

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Description

High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant

JHU 37152 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1.8 nM and 8.7 nM for hM3Dq and hM4Di in vitro, respectively; EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in vitro, respectively). Selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. Inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons. Brain penetrant in mice, rats and non-human primates.
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Specifications

Chemical Name or Material 8-Chloro-11-(4-ethylpiperazin-1-yl)-1-fluoro-5 H-dibenzo[b,e][1,4 ]diazepine
CAS 2369979-67-7
Quantity 10 mg
Target DREADD Activators
Molecular Formula C19H20ClFN4
Purity 0.98
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