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JAK2 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen 44406G
Code : 50
Additional Details : Weight : 0.50000kg
Description
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.Specifications
JAK2 | |
Polyclonal | |
Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3 | |
O60674, Q62120 | |
JAK2 | |
The antiserum was produced against a chemically synthesized peptide derived from the C-terminal region of human JAK2. The sequence is conserved in mouse and rat. | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
Western Blot | |
Unconjugated | |
JAK2 | |
EC 2.7.10.2; Fd17; JAK 2; JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; THCYT3; Tyrosine-protein kinase JAK2 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
16452, 3717 | |
-20°C | |
Liquid |