JAK1 Mouse anti-Human, Rat, Clone: 3H7A8, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66466-1-IG-20UL

Product Code. 16898365

Description

JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.

Specifications

• Antigen: JAK1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: P23458
• Gene Symbols: JAK1
• Immunogen: JAK1 Fusion Protein Ag17940
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Western Blot, Immunohistochemistry (Paraffin)
• Clone: 3H7A8
• Conjugate: Unconjugated
• Gene: JAK1
• Gene Alias: JAK 1, JAK1, JAK1A, JAK1B, Janus kinase 1, JTK3, Tyrosine protein kinase JAK1
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 3716, 84598
• Content And Storage: -20°C
• Form: Liquid