IWS1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
16836734	Proteintech 16943-1-AP-20UL	20 μL
16826734	Proteintech 16943-1-AP-150UL	150 μL

Description

Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.

Specifications

• Antigen: IWS1
• Applications: Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q3SWT4, Q8C1D8, Q96ST2
• Gene ID (Entrez): 291705, 55677, 73473
• Immunogen: IWS1 Fusion Protein Ag10554
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: IWS1

• Concentration: 0.25 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: IWS1, IWS1 homolog (S. cerevisiae), IWS1 like protein, IWS1L, Protein IWS1 homolog
• Gene Symbols: Iws1
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody