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  5. Tocris Bioscience™ Ivosidenib

Tocris Bioscience™ Ivosidenib
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Product Code. 18736926
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18736926 10 mg 10mg
18798656 50 mg 50mg
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Product Code. 18736926 Supplier Tocris Bioscience™ Supplier No. 7761/10

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Description

Potent inhibitor of mutant isocitrate dehydrogenase (mIDH1)

Ivosidenib is a potent inhibitor of mutant isocitrate dehydrogenase enzyme 1 (mIDH1), with activity against a variety of mutant IDH1 enzymes (IC50 range = 5-19 nM). Reduces intracellular 2-HG (Cat. No. 6122) by 96% at 0.5 μM. Increases sensitivity of melanoma to Temozolomide (Cat. No. 2706) in vivo and inhibits wild-type IDH1 in low magnesium and low nutrient levels. Ivosidenib also inhibits growth of tumors in cell and animal models of pancreatic cancer and inhibits invasion and migration of chondrosarcoma cells in vitro.
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Specifications

Chemical Name or Material (2S)-N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide
CAS 1448347-49-6
Quantity 10 mg
Target Isocitrate Dehydrogenase 1/IDH1
Molecular Formula C28H22ClF3N6O3
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