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Itraconazole, MedChemExpress

Product Code. 16407356
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Product Code. 16407356 Supplier Medchem Express Supplier No. HY17514100mg

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Description

MedChemExpress Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ∼800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.

Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ∼800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.

Specifications

Chemical Name or Material Itraconazole
Physical Form Solid
CAS 84625-61-6
Color White
Quantity 100 mg
Purity Grade Notes Research
Molecular Formula C35H38Cl2N8O4
For Use With (Application) COVID-19-immunoregulation
Synonym R51211
Solubility Information DMSO : 6.25 mg/mL (8.86 mM; Need ultrasonic)
SMILES ClC1=C(C=CC(Cl)=C1)[C@@]2(O[C@@H](COC3=CC=C(N4CCN(C5=CC=C(N(C=NN6C(C)CC)C6=O)C=C5)CC4)C=C3)CO2)CN7C=NC=N7
Molecular Weight (g/mol) 705.63
Formula Weight 705.63
Percent Purity 99.15%
Grade Research
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