Invitrogen™ ITPKB Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA536964

Product Code. 15594171

Description

This antibody detects endogenous protein at a molecular weight of 74 and 120 kDa. Purity is >95% by SDS-PAGE.

Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) regulates the level of calcium within the cell by releasing calcium from intracellular stores. Ins(1,4,5)P3 is phosphorylated by inositol 1,4,5-trisphosphate 3-kinase (IP3K) to form inositol 1,3,4,5-tetrakisphosphate (Ins(1,4,5)P4), which is is thought to regulate the influx of calcium across the plasma membrane. IP3K exists as three isoforms, IP3KA, B, and C. IP3KA, the most highly characterized isoform, is expressed in rat brain and testis. IP3KB is expressed in various rat tissues such as lung, thymus, testis, brain, and heart. IP3K activity is stimulated in the presence of calmodulin via phosphorylation by cAMP-dependent protein kinase, protein kinase C, or calcium/calmodulin dependent protein kinase II and, subsequently, mediates the inositol phosphate signaling pathways.

Specifications

• Antigen: ITPKB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ITPKB
• Gene Alias: 1110033J02Rik; E130307H12Rik; Inositol 1,4,5-trisphosphate 3-kinase B; inositol-trisphosphate 3-kinase B; insP 3-kinase B; IP3 3-kinase B; IP3-3KB; IP3K; IP3K B; IP3KB; IP3K-B; Itpkb; PIG37; proliferation-inducing protein 37
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 320404, 3707, 54260
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P27987, P42335
• Gene Symbols: ITPKB
• Immunogen: Synthetic peptide corresponding to amino acids 205-250 of human ITPKB.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG