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Invitrogen™ ITM2B Polyclonal Antibody

Product Code. 16380035
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
16380035 100 μL 100µL
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Product Code. 16380035 Supplier Invitrogen™ Supplier No. PA583079

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: YFALQPDDVY YCGIKYIKDD VILNEPSADA PAALYQTIEE NIKIFEEEEV EFISVPVPEF ADSDPANIVH DFNKKLTAYL DLNLDKCYVI PLNTSIVMPP RNLLELLINI KAGTYLPQSY LIHEHMVITD RIENIDHLGF FIYRLCH Highest antigen sequence indentity to the following orthologs: Mouse - 95%, Rat - 96%.

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ITM2B
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.10 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ITM2B
Gene Accession No. Q9Y287
Gene Alias ABRI; ABri/ADan amyloid peptide; ABri23; AI256040; Bri; BRI2; BRI2 ICD; BRI2 intracellular domain; BRI2, membrane form; Bri2-23; Bri23 peptide; BRI2C, soluble form; Bricd2b; BRICHOS domain containing 2B; C-terminal peptide; D14Sel6; E25B; E25BMM; E3-16; FBD; imBRI2; Immature BRI2; integral membrane protein 2B; Integral membrane protein 2B (E25B protein); ITM2B; Mature BRI2; mBRI2; OTTHUMP00000018394; P23 peptide; Protein E25B; RDGCA; RP11-196P14.1; Transmembrane protein BRI
Gene Symbols ITM2B
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ITM2B. Recombinant protein control fragment (Product #RP-102188).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9445
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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